Well, we aren't quite there yet, but scientists are making progress in developing genetically modified oral vaccines.
In one case, researchers are currently testing a plant based oral vaccine to protect cattle against a disease called pneumonic pasteurellosis, commonly known as "shipping fever" because cattle experience this stress-induced disease while being shipped from cow/calf operations to feedlots. During this respiratory illness, caused by the bacterium Mannheimia haemolytica, diseased cattle experience decreased appetite, fever and nasal discharge. An injectable vaccine against the disease is available, but it is costly and labor intensive and the injection is so stressful for cattle that it may actually contribute to the problem.
Hoping to develop an oral vaccine, researchers have genetically modified white clover so that the plant expresses one of M. haemolytica's proteind. The idea is that when cattle are fed the genetically altered clover, the bacterial protein will trigger a protective immune response. To date, the vaccine has worked successfully in laboratory animals.
source: Microbiolgy with Diseases by Taxonomy 2nd Edition. Robert W. Bauman Ph. D. Amarillo College
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